Fig. 1: Evolution of Cdx2 binding across gene promoters and enhancers supports developmental and homeostatic functions in intestinal epithelium. | Nature Communications

Fig. 1: Evolution of Cdx2 binding across gene promoters and enhancers supports developmental and homeostatic functions in intestinal epithelium.

From: Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis

Fig. 1

a Heatmap showing Cdx2 CUT&RUN signal at its developmental and adult-specific binding sites in embryonic (E12.5), fetal (E16.5), and adult epithelial (villus) cells; Dev 1–3 and Adult 1–3 subgroups represent 2-fold change (q < 0.01) in Cdx2 signal among the three timepoints. b Pie charts showing percentages of Cdx2 binding sites shown in (a) (Dev 1, 2 and Adult 1, 2) at promoters (TSS −2 kb to +1 kb) and distal enhancers. c Gain, retention, and loss of Cdx2 binding at promoters (top panel) and distal enhancers (bottom panel) during development from E12.5 into adult epithelial cells; numbers outside the boxes and inside the dotted boxes represent gains and losses of Cdx2 binding at each of the timepoints, respectively. d Genome browser tracks showing progressive loss or recruitment of Cdx2 through epithelial development at Sox4 and Fabp2 gene promoters, respectively.

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