Fig. 1: Distinct subtypes within ETV6::RUNX1 ALL.
From: Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia
a UMAP dimension reduction of the gene expression signature of the primary discovery cohort based on 252 genes identified using non-negative matrix factorization. b, c Comparison of b the age group and c the presenting white blood cell (WBC) count between the two subtypes in the primary discovery cohort. d UMAP of the validation cohort based on 122 genes identified independently on the validation cohort using non-negative matrix factorization. e, f Comparison of e the age group and f the presenting WBC between the two subtypes in the validation cohort. In b, c, e, f association between categorical variables are tested using Chi-squared test. Source data are provided as a Source Data file.
