Fig. 2: Signature of B cell differentiation of ETV6::RUNX1 ALL subtypes.
From: Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia
a Gene set enrichment analysis comparing the C2 versus C1 using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and WikiPathways (WP) databases. Pathways with adjusted P < 0.001 are shown. The significance of a pathway is tested by permutation and corrected for multiple testing using the Benjamini–Hochberg procedure. b Percentages of cells in different B cell differentiation stages using gene expression-based deconvolution analysis. Only stages along the B cell differentiation are included. c Comparison of the deconvoluted percentages of HSC-like, pre-pro-B-like, and pro-B-like cells between the two ETV6::RUNX1 subtypes. Difference between the two subtypes is tested using the two-sided Mann–Whitney U test. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers. HSC-like, hematopoietic stem cell-like; CLP-like, common lymphoid progenitor-like. Source data are provided as a Source Data file.
