Fig. 5: Influence of hemocyte depletion on host/restriction factors expression. | Nature Communications

Fig. 5: Influence of hemocyte depletion on host/restriction factors expression.

From: Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity

Fig. 5

NT, LPSM-injected, and CLD-injected mosquitoes were fed on blood, and then samples (whole body and midgut) were collected at 24 h post-blood feeding to analysis gene expression and proliferation. Heatmap of Log2 (-fold change) of antagonist and agonist genes of P. falciparum infection in the whole mosquito and midguts. Basal expression is indicated by the color white, upregulation by red, and downregulation by blue. Data were obtained from three independent experiments pulled together to generate the graph. Data are represented as Log2 means with SD, (n = 3). Statistical analysis was performed by ANOVA test, followed of Tukey´s multiple comparation test for fold changes values. #p < 0.1; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Data and detailed statistical analysis of the -fold changes are available in the Source Data file and Supplementary Figs. 7a–j, 8a–j. Schematic illustrations of the experimental strategy were created by Victor Cardoso-Jaime, using Microsoft PowerPoint Version 16.92.

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