Fig. 1: TCR maturation and TRBC clonality in selected peripheral T cell lymphoma cases. | Nature Communications

Fig. 1: TCR maturation and TRBC clonality in selected peripheral T cell lymphoma cases.

From: Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies

Fig. 1

a illustrates TRBC clonality in relation to the maturation stage of the lymphoma cell of origin. In panel b four characteristic cases of peripheral T cell lymphomas are highlighted with single-cell TRBC expression plots of sequenced T cells. Malignant T cells, defined by their listed clonotypic TRA or TRB CDR3 rearrangements, are colored according to their TRBC expression with bubble sizes normalized to the case-specific single cell read counts. Detailed definition of the clonotypic CDR3 rearrangements are listed in the “methods” section.

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