Fig. 1: Schematic illustration of dual-drug depots for preventing postoperative tumor recurrence.

a Preparation of the DOX-loaded electrospun fibers. b Fabrication of the dual-drug depots composed of two pieces of MSA-2-loaded 3D-printed scaffolds sandwiching one patch of DOX-loaded electrospun fibers. c Tumor excision with positive margins, dual-drug depot implantation, controlled drug release, and mechanisms for the cascade-reinforced cycle of immunotherapy and chemotherapy inhibiting postoperative tumor recurrence.