Fig. 2: Properties of dual-drug depots. | Nature Communications

Fig. 2: Properties of dual-drug depots.

From: Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers

Fig. 2

Schematic diagrams, digital photographs (a), and representative SEM images (b) of the electrospun fiber patch, the 3D-printed scaffold, and the pseudo-color scaffold-fiber-scaffold sandwich-like composite (yellow, 3D-printed scaffolds; red, electrospun fibers) (n = 3 independent experiments in b). c Diameter distribution of electrospun fibers calculated based on SEM images. d Representative fluorescence images of DOX-loaded electrospun fibers (n = 3 independent experiments). Rheological behaviors (e), thixotropies (solid squares, G’, storage modulus; hollow squares, G”, loss modulus) (f), and Tanδ values (the ratio of G”/G’) (g) of the bioink with or without Ca2+ or MSA-2 as a function of oscillatory strain at a constant shear frequency of 1 Hz. Relative cumulative release profiles of MSA-2 (orange dots) (h) and DOX (red dots) (i) from dual-drug depots at pH 7.4 (solid dots) (j) or pH 6.5 (hollow dots) (k) (n = 3 independent experiments). Data are shown as mean ± SD. Source data are provided as a Source Data file.

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