Fig. 3: Overlay of S4 [S4d1, S4d2] and S5 states showing intermediate transitions.
From: Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex
a Superimposed licorice representations of S4 [S4d1, S4d2]-mini-Gαsβγ aligned by TM1, with key motions highlighted using cylinders. The front view illustrates a slight shift in adenosine binding and key transitions near TM6, Cα5, and αN helices, also shown in the right side view. b Superimposed licorice representations of S5, S4 [S4d1, S4d2]-mini-Gαsβγ, with key motions highlighted using cylinders. The front view focuses on transitions near TM6, Cα5, and αN helices. c C-α displacement representation of the S5 state, with a dashed outline indicating the corresponding S4 state for reference. The C-α displacement color bar, mapped to each C-α atom, ranges from 0.0 Å (teal) to 6.0 Å (red), with intermediate values at 2.0 Å (light yellow) and 4.0 Å (peach).
