Fig. 2: Interrogation of shared and unique enhancers across the MYC locus via massively-parallel genetic perturbations in six cell lines. | Nature Communications

Fig. 2: Interrogation of shared and unique enhancers across the MYC locus via massively-parallel genetic perturbations in six cell lines.

From: Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

Fig. 2

a CRISPR inhibition (CRISPRi) screen tiling across a 2.8 Mb topologically-associated domain containing the oncogene MYC using ~112,000 gRNAs. b MYC expression and CRISPR screen depletion (Chronos) scores from Broad DepMap (n = 1021 cell lines). c Sliding window analysis for identification of cis-regulatory elements (CREs). d Upset plot of shared and cell-specific enhancer-like CREs across six pooled CRISPRi screens. Source data are provided as a Source Data file.

Back to article page