Fig. 6: Predicted transcription factors at CREs in the MYC locus are tissue specific. | Nature Communications

Fig. 6: Predicted transcription factors at CREs in the MYC locus are tissue specific.

From: Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

Fig. 6

a Identification of transcription factor binding at CREs and summary of key transcription factors found. b Number of transcription factors significantly enriched in the CREs from 1 or more cell lines. c Fold enrichment for top 25 transcription factors in each cell line. d Transcription factor ChIP-seq for selected transcription factors from panel c. JUNB, JUN, and FOSL2 ChIP-seq are from A549, GATA2 ChIP-seq is from K562, THAP11 ChIP-seq is from HepG2 and ETS1 ChIP-seq is from SCC25. e Correlation in primary tumors from The Cancer Genome Atlas (TCGA) between MYC expression and top-ranked transcription factors from panel (c). TCGA tumor types are matched to the same cell/tissue type as CRISPRi cell lines in which the transcription factor is enriched (n = 2855 TCGA primary tumors; LUAD: n = 512, COAD: n = 594, SKCM: n = 472, AML: n = 175, BRCA: n = 1102 tumors). Source data are provided as a Source Data file.

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