Fig. 5: Transcriptomic analysis of Acute Myeloid Leukemias with low expression of LUC7L2.
From: LUC7 proteins define two major classes of 5′ splice sites in animals and plants
A Normalized gene expression values for human LUC7 family in LAML samples, colored by whether samples possess a LUC7L2 CNV loss (CNV log2 value < –0.5). A two-sided t-test was used to test differences in LUC7 paralog expression between LUC7L2+/+ (n = 159) and LUC7L2 CNV loss (n = 14). B Overlap of LUC7L2 CNV loss samples and LUC7L2Low expression samples. C Mean dPSI per 5′ splice site sequence for differentially spliced exons when comparing LUC7L2Ctrl versus LUC7L2Low expression samples. A linear regression line (black) with a 95% confidence interval is shown, and the Pearson correlation and Pearson correlation test are displayed. D Gene set enrichment analysis of differentially expressed genes comparing LUC7L2Low versus LUC7L2Ctrl expression samples. E Copy-number variation analysis for LUC7L2 and LUC7L3 loci across all TCGA cancer types. ***p < 0.001, Bonferroni-corrected two-sided Wilcoxon-rank sum test. For panels A and E, boxplots display the data distribution within each group. The box represents the interquartile range (IQR), spanning from the 25th percentile (Q1) to the 75th percentile (Q3), with the horizontal line inside the box indicating the median (50th percentile). The whiskers extend to the most extreme data points within 1.5 times the IQR from Q1 and Q3. Source data are provided as a Source Data file.
