Fig. 6: Related LUC7 proteins possess conserved specificities for 5′SS subclasses.
From: LUC7 proteins define two major classes of 5′ splice sites in animals and plants
A Maximum likelihood phylogenetic tree built from multiple sequence alignment of Luc7 proteins from 33 animal, fungal and plant species, adding Trichomonas vaginalis Luc7 protein as an outgroup. Two main clusters are shaded to indicate Luc7 subfamilies; individual proteins represented by symbols indicating clade of origin. B Representation of presence/absence and likely duplication/loss events for Luc7 subfamilies overlaid on the eukaryotic phylogenetic tree. C Correlation matrix of 5′SS models learned from dinucleotide features of 5′SS differentially spliced in human and plant Luc7 RNA-seq experiments. D Sequence logos of top or bottom 10% unique 5′SS sequences identified by dinucleotide 5′SS models. E Residue conservation estimated from multiple sequence alignment of LUC7L2-type proteins from 6A), projected onto the yLUC7p (from Bai et al., 2018) cryo-EM protein structure.
