Fig. 5: Dopaminergic medication effects on state-specific functional connectivity patterns in Parkinson’s disease (PD) group. | Nature Communications

Fig. 5: Dopaminergic medication effects on state-specific functional connectivity patterns in Parkinson’s disease (PD) group.

From: Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson’s disease

Fig. 5

A BSDS identified differences in functional connectivity patterns of the encoding-associated brain state (i.e., S1) between PD-OFF and PD-ON groups. Compared to PD-ON, PD-OFF had significantly increased functional connectivity between DMPFC and bilateral AI. Also, right Thalamus showed increased functional connectivity with left AI and decreased functional connectivity with right Caudate, respectively (p < 0.05, two-tailed t-test, FDR corrected, nPD = 27). B BSDS also identified difference in functional connectivity patterns of the maintenance-retrieval-associated brain state (i.e., S4) between PD-OFF and PD-ON groups. Compared to PD-ON, PD-OFF had significantly increased functional connectivity of Thalamus with DLPFC, DMPFC, and AI, and had significantly reduced functional connectivity between left and right Thalamus (p < 0.05, two-tailed t-test, FDR corrected, n nPD = 27). A, B The ROIs include bilateral posterior parietal cortex (PPC), dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), anterior insula (AI), caudate (Cau), and thalamus. All exact p-values are provided in Source Data. Source data are provided as a Source Data file.

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