Fig. 6: Medication effect on functional connectivity pattern of brain states and task performance in the Parkinson’s disease (PD) group.
A Medication effect on functional connectivity brain states and task performance in PD. We examined significant modes of covariation between dynamic brain measures of brain state (assessed using changes of functional connectivity in encoding-associated and maintenance-retrieval-associated brain states), and task performance (assessed using changes in task performance including accuracy and reaction time). B Canonical correlations showing modes against the null distribution of the permuted canonical correlations estimated via permutation testing (r = 0.95, p < 0.05, permutation test, FDR-corrected, nPD = 27). This analysis revealed a significant Canonical Correlation Analysis (CCA) component that represents significant medication-related changes in functional connectivity and task performance in DL condition. C Prediction analysis performed using leave-one-out cross-validation revealed that, based on changes in functional connectivity pattern in State 1 and State 4, our CCA model can predict changes in task performance of PD patients on unseen data (r = 0.76, p = 0.019, Pearson’s Correlation, nPD = 27). D CCA weights associated with each canonical variate are shown. Variables showing significant contribution to the CCA mode are marked in yellow (p < 0.05, FDR-corrected, Pearson’s Correlation, nPD = 27, see Methods for details). B–D Source data are provided as a Source Data file.
