Fig. 7: Celecoxib and OSPPB hydrogel exhibit remarkable pain-alleviating functionality. | Nature Communications

Fig. 7: Celecoxib and OSPPB hydrogel exhibit remarkable pain-alleviating functionality.

From: Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis

Fig. 7

a Representative tracks of mice at 3 weeks in the CON and UAC groups, as documented in the EPM test, with the corresponding statistical results (c–e). One-way ANOVA is followed by the Tukey-Kramer method for post hoc multiple comparisons in (c, d). n = 6, F(3, 20) = 16.83, p < 0.0001 in (c). n = 6, F(3, 20) = 3.696, p = 0.0289 in (d). n = 6, H(3) = 11.6, p = 0.0089 in (e). b Representative tracks of mice in the OFT, with the corresponding statistical results (f–h). One-way ANOVA accompanied by the Tukey-Kramer method is used for post hoc multiple comparisons. n = 6, F(3, 20) = 19.4, p < 0.0001 in (f). n = 6, F(3, 20) = 31.85, p < 0.0001 in (g). n = 6, F(3, 20) = 13.68, p < 0.0001 in (h). i Results of the von Frey test revealing the pain relief after different treatments (n = 6, H(3) = 10.21, p = 0.0168). Reproduced under the terms of a Creative Commons Attribution license (CC-BY-4.0)20. j EEG spectrograms of the stimulus before and after small brush stimulation. Created in BioRender. Data are shown as the means and standard deviations. One-way ANOVA is followed by the Tukey-Kramer method for post hoc multiple comparisons in (c, d, f–h). Kruskal–Wallis (KW) test is followed by Dunn’s test for post hoc multiple comparisons in (e, i).

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