Fig. 8: The OSPPB hydrogel effectively attenuates neurovascularization at the osteochondral interface. | Nature Communications

Fig. 8: The OSPPB hydrogel effectively attenuates neurovascularization at the osteochondral interface.

From: Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis

Fig. 8

a Representative images of the distribution of exRNA at the osteochondral interface of condyles in the CON and UAC groups at 3 weeks after different treatments. b Representative images of the trigeminal ganglion anterograde tracing and immunofluorescence staining of nerves (PGP9.5 and CGRP), vessels (CD31), and VEGF. c Representative images of the distribution of pain-related factors (COX2, DCC, and SP). d The semi-statistical analysis of (a). e–h The semi-statistical analysis of (b). i–k The semi-statistical analysis of (c). n = 6, F(3, 20) = 213.6, p < 0.0001 in (d). n = 6, F(3, 20) = 66.07, p < 0.0001 in (e). n = 6, F(3, 20) = 146.4, p < 0.0001 in (f). n = 6, F(3, 20) = 96.29, p < 0.0001 in (g). n = 6, F(3, 20) = 57.17, p < 0.0001 in (h). n = 6, F(3, 20) = 130.5, p < 0.0001 in (i). n = 6, F(3, 20) = 159.9, p < 0.0001 in (j). n = 6, F(3, 20) = 143.9, p < 0.0001 in (k). Scale bars = 50 μm (left in a), 10 μm (right in a), 30 μm (b, c). Data are shown as the means and standard deviations. One-way ANOVA is followed by the Tukey-Kramer method for post hoc multiple comparisons.

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