Fig. 2: Scheme of the synthesis of caged Plk1 inhibitor cPlk1i.

a triphosgene, DIPEA, THF, 0 °C, 30 minutes; b 1) 5, NaH, THF, 0 °C, 30 minutes, 2) DIPEA, THF, 0 °C, 63% yield.
a triphosgene, DIPEA, THF, 0 °C, 30 minutes; b 1) 5, NaH, THF, 0 °C, 30 minutes, 2) DIPEA, THF, 0 °C, 63% yield.