Fig. 4: Viremia is strongly associated with proliferated cell clones of smaller size. | Nature Communications

Fig. 4: Viremia is strongly associated with proliferated cell clones of smaller size.

From: Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns

Fig. 4

a–c Mosaic plots of the number of +viremia and -viremia proviruses associated with proliferated and non-proliferated cell clones during early and rebound infections (a), early infection only (b), or rebound infection only (c). Odds ratio (OR) of detecting proviruses associated with cellular clonal proliferation among proviruses associated with or without viremia. P value was calculated by two-sided Fisher’s exact test. d Among proliferated cell clones, the UMI per IS of cell clones harboring +viremia or -viremia proviruses. n represents the number of IS among proliferated cell clones. P value was calculated using the two-tailed Mann-Whitney test. e Correlation of natural log transformed mean cell clone size (UMI per IS) and viral seeding (IS per BC) among +viremia proviruses in proliferated cell clones during early (left) and rebound (right) infections. Black trendline line calculated by simple linear regression. Spearman’s rank correlation coefficient (r) and associated p values. Early, n = 23; Rebound, n = 27. Source Data Fig. a–e.

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