Fig. 5: Minor proportion of proviruses associated with cell clonal proliferation were in genes associated with tumorigenesis. | Nature Communications

Fig. 5: Minor proportion of proviruses associated with cell clonal proliferation were in genes associated with tumorigenesis.

From: Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns

Fig. 5

a, b Frequency of IS location in genes related to cancer based on COSMIC data base between all proviruses and the normal distribution of these genes in the human genome (a) or proviruses in proliferated versus non-proliferated cell clones (b). P value was calculated using the two-tailed Mann-Whitney test. c Dot plot representing the integration events that were enriched in genes among proliferated versus non-proliferated cell clones. Odds ratio and p values were calculated by two-sided Fisher’s exact test. Y-axis indicates the p value (-log10). X-axis indicates the chromosome number and position. Red dashed line indicates the threshold for statistical significance after Bonferroni correction of p value of 0.05. d Contribution of integration sites in the listed genes among proliferated cell clones. e Among proliferated cell clones, the cell clone size (UMI per IS) for each integration site. Horizontal bars represent the mean. TNFRSF10D vs all other, p = 0.0044; FOXP4 vs all other, p = 0.0178. WWC1, NBPF12, or TNFRSF10B vs all other, p > 0.05. The adjusted p values were calculated by comparing the UMI per IS for each of the listed gene to the UMI per IS for all other genes by Kruskal-Wallis test. Source Data a–e.

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