Fig. 6: Proviruses in proliferated cell clones are associated with activating chromatin features. | Nature Communications

Fig. 6: Proviruses in proliferated cell clones are associated with activating chromatin features.

From: Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns

Fig. 6

a Heat map demonstrating the odds ratio of proviruses with the listed epigenetic features. Three different comparisons were made: all proviruses versus randomly generated control (left) and proviruses from proliferated versus non-proliferated cell clones (right). The odds ratios and the p values were calculated using the two-sided Fisher’s exact test. n.s., P > 0.05. b Log10 transformed chromosomal distance (bp) to the nearest histone modification among proviruses from proliferated versus non-proliferated cell clones. n represents the number of proviruses. c–e Log10 transformed chromosomal distance (bp) to the nearest transcription start site (TSS) (c), same-direction TSS (d), and ATAC-peak among proviruses (e) among proviruses from proliferated versus non-proliferated cell clones. n represents the total number of proviruses (c, e) or number of same-orientation proviruses (d). Horizontal bars represent mean ± SD. n.s., p > 0.05. P values were calculated using the two-tailed Mann-Whitney test (b–e). Source Data Fig. a–e.

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