Table 1 Characteristics of lung cancer cases who have never smoked diagnosed between 1998-2019 and matched controls who have never smoked in CPRD-GOLD and CPRD-Aurum
From: Inflammatory diseases and risk of lung cancer among individuals who have never smoked
Discoverya data (CPRD-GOLD) | Validationa data (CPRD-Aurum) | |||
|---|---|---|---|---|
Characteristic | Cases (n = 1581) | Controls (n = 14,318) | Cases (n = 2188) | Controls (n = 19,597) |
Age (years) at selection/diagnosis, n (%) | ||||
30–39 | 18 (1.1) | 198 (1.4) | 38 (1.7) | 362 (1.8) |
40–49 | 77 (4.9) | 689 (4.8) | 92 (4.2) | 917 (4.7) |
50–59 | 168 (10.6) | 1581 (11.0) | 249 (11.4) | 2359 (12.0) |
60–69 | 356 (22.5) | 3240 (22.6) | 445 (20.3) | 4189 (21.4) |
70–79 | 522 (33.0) | 4560 (31.8) | 681 (31.1) | 6113 (31.2) |
80–89 | 440 (27.9) | 4050 (28.3) | 683 (31.2) | 5657 (28.9) |
Female, n (%) | 891 (56.4) | 8338 (58.2) | 1265 (57.8) | 11471 (58.5) |
Year of practice registration, n (%) | ||||
1980 and earlier | 409 (26.0) | 3588 (25.1) | 551 (25.2) | 4612 (23.5) |
1981–1990 | 325 (20.6) | 2893 (20.2) | 479 (21.9) | 4351 (22.2) |
1991–2000 | 430 (27.2) | 3793 (26.5) | 618 (28.2) | 5663 (28.9) |
2001–2010 | 335 (21.2) | 3246 (22.7) | 403 (18.4) | 3697 (18.9) |
2011–2018 | 82 (5.2) | 798 (5.6) | 137 (6.3) | 1274 (6.5) |
Index year, n (%) | ||||
1989–1994 | 43 (2.7) | 343 (2.4) | 9 (0.4) | 74 (0.4) |
1995–2000 | 173 (10.9) | 1455 (10.2) | 256 (11.7) | 2322 (11.8) |
2001–2006 | 397 (25.1) | 3221 (22.5) | 523 (23.9) | 4645 (23.7) |
2007–2012 | 534 (33.8) | 5024 (35.1) | 671 (30.7) | 5985 (30.5) |
2013–2019 | 434 (27.5) | 4275 (29.9) | 729 (33.3) | 6571 (33.5) |
Duration of registration in practice, year (IQR) | 15.1 (6.3, 28.5) | 14.9 (6.3, 28.3) | 16.2 (7.4, 28.3) | 15.6 (7.32,27.4) |
Body Mass Index (kg/m2), n (%) | ||||
Underweight (< 18.5) | 19 (1.2) | 196 (1.4) | 41 (1.9) | 269 (1.4) |
Normal weight (18.5–24.9) | 459 (29.0) | 3937 (27.5) | 671 (30.7) | 5774 (29.5) |
Overweight (25.0–29.9) | 467 (29.5) | 4246 (29.7) | 722 (33.0) | 5857 (29.9) |
Obese (≥ 30.0) | 248 (15.7) | 2294 (16.0) | 331 (15.1) | 3250 (16.6) |
Missing | 388 (24.5) | 3645 (25.5) | 423 (19.3) | 4447 (22.7) |
Alcohol Consumption, n (%) | ||||
Current | 824 (52.1) | 7103 (49.6) | 1574 (71.9) | 13204 (67.4) |
Former | 95 (6.0) | 804 (5.6) | 34 (1.6) | 394 (2.0) |
Never | 267 (16.9) | 2252 (15.7) | 134 (6.1) | 1021 (5.2) |
Missing | 395 (25.0) | 4159 (29.0) | 446 (20.4) | 4978 (25.4) |
Region, n (%) | ||||
East Midlands | 29 (1.8) | 276 (1.9) | 60 (2.7) | 543 (2.8) |
East of England | 73 (4.6) | 679 (4.7) | 133 (6.1) | 1226 (6.3) |
London | 177 (11.2) | 1563 (10.9) | 271 (12.4) | 2325 (11.9) |
North East | 9 (22.5) | 56 (0.4) | 105 (4.8) | 1027 (5.2) |
North West | 138 (33.0) | 1245 (8.7) | 395 (18.1) | 3338 (17.0) |
Northern Ireland | 45 (2.8) | 458 (3.2) | – | – |
Scotland | 355 (22.5) | 3153 (22.0) | – | – |
South Central | 111 (7.0) | 999 (7.0) | 221 (10.1) | 1987 (10.1) |
South East Coast | 144 (9.1) | 1334 (9.3) | 175 (8.0) | 1494 (7.6) |
South West | 100 (6.3) | 925 (6.5) | 330 (15.1) | 3085 (15.7) |
Wales | 256 (16.2) | 2388 (16.7) | – | – |
West Midlands | 112 (7.1) | 976 (6.8) | 398 (18.2) | 3589 (18.3) |
Yorkshire and the Humber | 32 (2.0) | 266 (1.9) | 100 (4.6) | 983 (5.0) |
