Fig. 7: CellHit predictions on distinct PDAC subtypes and experimental validation.
From: Learning and actioning general principles of cancer cell drug sensitivity
A Enrichment of predicted cancer cell lines that react most similarly to the available drugs for the Glandular (GL) and Transitional (TR) subtypes. Classification of the tissue types of cell lines (oncotree system) is shown; B Heatmap of predicted IC50 (predIC50) of GDSC drugs derived by CellHit prediction in PDAC samples. K-means clustering (n_clusters=2, method=Euclidean distance) was performed. Subtype annotations are shown for each sample; C Violin plot showing the predicted IC50 (predIC50) of Gemcitabine for the Glandular (GL) and Transitional (TR) subtypes; D Euclidean distance derived from Celligner between each PDAC cell line (CFPAC-1, PANC-1) and each selected tumor type (Pancreatic, Esophagogastric, Invasive Breast, Head and Neck); E Violin plot showing the predicted IC50 (predIC50) of Irinotecan and Etoposide for the Glandular (GL) and Transitional (TR) subtypes; F percentage of cell viability of CFPAC-1 and PANC-1 cells treated with increasing concentrations of Irinotecan or Etoposide at 24, 48 and 72 h. Individual values represent the average of three independent experiments ±SD. Source data are provided as a Source Data file.
