Fig. 6: Taxa showing significant differences in abundance between PD and controls (CTR). | Nature Communications

Fig. 6: Taxa showing significant differences in abundance between PD and controls (CTR).

From: Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease

Fig. 6

a Univariate differential abundance testing was performed independently for each dataset using Agresti Generalised Odds ratios on the taxa obtained from 16S and SMG profiles. Results (Generalised odds) were pooled using random effect meta-analysis and displayed together with 95% confidence intervals. Tests were performed using all samples (see Table 1) of the 17 16S and 7 SMG datasets (see Methods for details). b Number of individual studies in which each taxon significantly differs in abundance between PD and controls. c Average Ridge regression coefficients and standard deviations calculated from all models built on each dataset (17 and 7 models for 16S and SMG data, respectively). Only 40 taxa with the largest effect sizes are shown. Genera and mOTUs with similar directions of enrichment across 16S and SMG data are displayed in bold.

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