Fig. 2: Subcluster analysis indicated the difference in OLs of the hippocampus in db/db mice.
From: SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice
a Heat map showing well-established gene marker expression to identify oligodendrocyte subclusters. b t-SNE plot presenting the oligodendrocyte subclusters of the hippocampus. c Bar chart and (d) t-SNE plot presenting relative abundances of oligodendrocyte subclusters from the db/m and db/db mice. e Differentiation trajectories of these subclusters were analyzed using Slingshot. Violin plot showing the expression of myelin-related genes (f) Mbp, (g) Sox10, (h) Myrf and (i) Dlg4 in the oligodendrocyte subclusters. j Heat map showing presenting the representative KEGG enrichment pathways in oligodendrocyte subclusters. Data are analyzed by unpaired two-tailed Student’s t-tests for (f–i) and hypergeometric test for (j). Source data are provided as a Source data file. COP, differentiation-committed oligodendrocyte precursors; KEGG, Kyoto Encyclopedia of Genes and Genomes; MFOL, myelin-forming oligodendrocytes; MOL, mature oligodendrocytes; NFOL, newly formed oligodendrocytes; OPC, oligodendrocyte precursor cell.
