Fig. 3: Myelination was reduced in the hippocampus of db/db mice.
From: SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice
a Representative images of LFB staining in db/m and db/db mice. Scale bar: 200μm (corpus callosum, hippocampus) and 50μm (cortex). b Representative immunofluorescence images of MBP expression in db/m and db/db mice. Scale bar: 200μm and 50μm (hippocampus), and 50μm (cortex). c Quantification of immunofluorescence images from (b), n = 4 mice per group. d Western blot analysis of the expression of MBP in db/m and db/db mice. e Quantification of protein bands from (d), n = 5 mice per group. f Western blot analysis of the expression of SOX10 in db/m and db/db mice. g Quantification of protein bands from (f), n = 5 mice per group. h Western blot analysis of the expression of PSD95 in db/m and db/db mice. i Quantification of protein bands from (h), n = 5 mice per group. Data are presented as mean ± SEM, and analyzed by unpaired two-tailed Student’s t-tests. Source data are provided as a Source data file. LFB, Luxol fast blue.
