Fig. 4: The loss of Nogo-A/B lowers blood pressure in both lean and obese mice. | Nature Communications

Fig. 4: The loss of Nogo-A/B lowers blood pressure in both lean and obese mice.

From: Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases

Fig. 4

A Radiotelemetry measurements of blood pressure (BP) (Created in BioRender. Di Lorenzo, A. (2025) https://BioRender.com/i50g226). Systolic BP (SBP; B), diastolic BP (DBP; C), and mean BP (MBP; D) were measured by radiotelemetry for 3 consecutive days following the recovery from surgery of ca. 12 days. (Nogo-A/B-deficient SD, n = 6 mice; Nogo-A/B-deficient HFD, n = 9 mice, WT SD and HFD, n = 10 mice per group). Data were expressed as mean ± SEM. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Statistical analysis was performed with two-way ANOVA with Sidak multiple comparisons test. Source data are provided as a Source Data file.

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