Table 1 Fragment elaborations, inhibitory potencies, and thermal stabilizations
From: Virtual fragment screening for DNA repair inhibitors in vast chemical space
Cmpd | Structure | pIC50a | ∆Tm (K)b |
|---|---|---|---|
5 |
| 4.24 ± 0.18 | 4.1 ± 0.7 |
6 |
| 4.44 ± 0.38 | 1.1 ± 0.5 |
7 |
| 5.18 ± 0.05 | 5.5 ± 1.2 |
8 |
| 5.19 ± 0.08 | 5.4 ± 0.5 |
11 |
| 5.89 ± 0.06 | 4.8 ± 0.4 |
17 |
| 6.22 ± 0.13 | 8.1 ± 0.1 |
23 |
| 6.22 ± 0.10 | 9.0 ± 0.2 |
