Fig. 2: Skeletal muscle fiber heterogeneity beyond MYHs.
From: Human skeletal muscle fiber heterogeneity beyond myosin heavy chains
A Principal component analysis (PCA) plots of transcriptomics and proteomics datasets colored by MYH-based fiber type. B Enrichment analysis of transcript and protein drivers of PC2 and PC1. Statistical analysis was performed using the clusterProfiler package with Benjamini-Hochberg adjusted p-values. C, D PCA plot colored by cell-cell adhesion gene ontology (GO) term in the transcriptome, and by costamere GO term in the proteome. Arrows represent transcript and protein drivers and their direction. E, F Uniform manifold approximation and projection (UMAP) feature plots of clinically relevant features displaying a slow/fast fiber type-independent gradient of expression. G, H Correlation between drivers of PC2 and PC1 between the transcriptome and proteome.
