Fig. 3: Ribosomal heterogeneity drives fiber type-independent heterogeneity.
From: Human skeletal muscle fiber heterogeneity beyond myosin heavy chains
A Principal component analysis (PCA) plot colored by cytosolic ribosome gene ontology (GO) term in the proteome. Arrows indicate the direction towards which the proteins are driving the variance in the PCA plot. The length of the lines represents the principal component score for a given protein. B, C PCA feature plots of RPS13 and RPL38. D Unsupervised hierarchical clustering analysis of proteins constituting the cytosolic ribosome. E Structural model of the 80S ribosome (PDB: 4V6X) highlighting ribosomal proteins displaying variable abundance across skeletal muscle fibers. F Ribosomal proteins with variable stoichiometry located close to the mRNA exit tunnel.
