Fig. 1: Structure of LAT1 bound to JPH203.
From: Structural basis of anticancer drug recognition and amino acid transport by LAT1
a Chemical structures of selected LAT1 substrates and inhibitors. b Cryo-EM map and the overall structure of LAT1 bound to JPH203. The map of the transmembrane domain after local refinement is shown. Nanodisc densities are not displayed for clarity. c Close-up view of the JPH203-binding site overlayed with the map.
