Fig. 3: Cryo-EM structures of LAT1 bound to Phe and melphalan or in apo in the outward-facing conformation.
From: Structural basis of anticancer drug recognition and amino acid transport by LAT1
a Overlay of the Phe- and melphalan-bound LAT1, with the ligands displayed as stick models. The square indicates the region zoomed up in panels (b–h). b Superposition of the Phe-bound, melphalan-bound and apo LAT1 structures, viewed from two different angles. The dotted circles highlight the bis-(2-chloroethyl)amino group of melphalan, accommodated in a hydrophobic space created by TM3, TM6a and TM10. c, f Structure of Phe-bound LAT1 in the outward-open conformation. d, g Structure of melphalan-bound LAT1 in the outward-open conformation. e, h Structure of apo LAT1 in the outward-open conformation.
