Fig. 4: Increase of EDA2R is reinforced by elevation of EDA-A2 in aging-associated comorbidities. | Nature Communications

Fig. 4: Increase of EDA2R is reinforced by elevation of EDA-A2 in aging-associated comorbidities.

From: Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

Fig. 4

The figure summarizes our findings, illustrating the tissue-wide correlation analysis that identified EDA2R as the top-ranking gene associated with aging across multiple tissues. The observed increase in EDA2R expression is accompanied by elevated levels of its ligand, EDA-A2, under specific aging-related conditions such as insulin resistance, type 2 diabetes (T2D), and obesity. Enhanced activation of the EDA2R/EDA-A2 signaling axis triggers parainflammatory responses, representing a potential therapeutic target for intervention using EDA2R-specific antagonists. Created in BioRender. Bolis, M. (2025) https://BioRender.com/u99v533.

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