Fig. 1: Summary of study design, analytical approaches, and key findings.

Main analyses were conducted on 1694 one-to-one matched Olink-SomaScan reagent pairs in 3976 CKB participants. Results were corrected for multiple testing using false discovery rate within each platform. Risk prediction models for IHD were built using conventional risk factors (age, sex, smoking, type 2 diabetes, systolic blood pressure, and waist circumference) and 1694 matched proteins. CKB China Kadoorie Biobank, IHD ischaemic heart disease, NRI net reclassification index.