Fig. 2: Observational correlations, associated factors, and comparison of pQTLs for 1694 proteins measured using both Olink and SomaScan platforms. | Nature Communications

Fig. 2: Observational correlations, associated factors, and comparison of pQTLs for 1694 proteins measured using both Olink and SomaScan platforms.

From: Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults

Fig. 2

Analyses were conducted for 1694 matched proteins among 3976 participants. a Observational correlations between Olink and SomaScan, with shaded areas indicating proteins with colocalising cis-pQTLs. b Features predictive of Spearman’s rho and their importance in Boruta feature selection. 28 of 87 features were selected by Boruta with p values < 0.01 (two-sided). Importance measures represent Z-scores of mean decrease accuracy measure with normalised permutation. The centre, bounds, and whiskers of boxes represent the median, first/third quartile, and 1.5 times the interquartile range of the data. c Number of sentinel pQTLs identified in Olink and SomaScan, with shaded areas indicating the number of proteins with pQTLs. d Number of proteins with cis-pQTLs identified in Olink and SomaScan, and number of which had cis-pQTLs that colocalised between the platforms. pQTL protein quantitative trait loci.

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