Fig. 6: Association analyses for cancer risk in PLCO and relative leukocyte telomere length (rLTL) in UKB cancer-free individuals.
a Evaluation of cancer risk in the PLCO dataset (n = 102,708) for the VNTR6-1-Long and rs10069690-T alleles and the composite marker (VNTR6-1/rs10069690). Odds ratios (ORs) are shown as squares with 95% confidence intervals (CIs) calculated for comparisons between patients with the indicated cancers and a common group of cancer-free controls using logistic regression analysis with an additive genetic model adjusted for sex and age. b Evaluation of the relationships in UKB cancer-free individuals (n = 339,103) between rLTL and VNTR6-1/rs10069690 and rs7705526 (LD, r2 = 0.33 between VNTR6-1/rs10069690 and rs7705526). P-values and β-values were derived from linear regression models adjusted for sex, age, and smoking status. Pint represents the interaction between genotypes and 5-year age groups; Pcond represents the mutual adjustment for rs7705526 or VNTR6-1/rs10069690. The graphs display regression lines and equations, with a shaded area representing the 95% confidence intervals. The analysis revealed a decrease in the rLTLs with more copies of the Short-C haplotype. The results of sex-specific analyses of VNTR6-1/rs10069690 are presented in Supplementary Fig. 21b. The details are provided in the Source Data file.
