Fig. 3: Antibiotic Treatment Significantly Improves the Recording Performance of Intracortical Microelectrodes.
Neurophysiological recordings to evaluate the performance of our intracortical microelectrodes and the impact of antibiotic treatment compared to control. Blue indicates control while orange indicates antibiotic groups. Comparisons are made to evaluate A the week-by-week proportion of active electrodes and B the acute, sub-chronic, and chronic grouped proportion of active electrodes. Additional metrics were evaluated to measure the C peak-to-peak voltage (Vpp), D root-mean-squared of the noise, E spike-rate of the single units, and F signal-to-noise ratio (SNR) of all active channels. The sample size for all comparisons is included as well. A one-tailed proportions z-test was used for calculating statistical differences in the proportion of active electrodes within and across groups for the acute, sub-chronic, and chronic phases. Peak-to-peak voltage, noise, spiking rate, and signal-to-noise ratio were compared within and across acute, sub-chronic, and chronic neuroinflammatory phases using a Kruskal-Wallis test followed by a Benjamini–Krieger–Yekutieli test to adjust for multiple comparisons for non-normal distributions to increase statistical power and reduce type I errors. Statistically significant p-values are displayed in the figure. No symbol or the abbreviation “ns” indicates a lack of statistical significance. No comparisons were made between antibiotic and control at differing time points. Created in BioRender. Capadona, J. (2025) https://BioRender.com/p93j360.
