Fig. 7: Spatial and Cell-Specific Analysis of the Implant Site Using Proteomics and Transcriptomics. | Nature Communications

Fig. 7: Spatial and Cell-Specific Analysis of the Implant Site Using Proteomics and Transcriptomics.

From: Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance

Fig. 7

A Proteomics analysis was performed on the entire implant ring (0–270 µm from the implant site), inner ring (0–90 µm from the implant site), middle ring (90–180 µm from the implant site), and outer ring (180–270 µm from the implant site) on a cell-specific basis for neurons, astrocytes, and all cells. B Transcriptomic analysis was not done using cell-specificity. Only spatial separation to analyze the implant regions was performed. Created in BioRender. Capadona, J. (2025) https://BioRender.com/p93j360.

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