Table 1 NanoString neural proteomic panel

From: Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance

Protein Symbol	Module	Function
ATG12	Autophagy	Autophagosome Formation
ATG5	Autophagy	Autophagosome Formation
BAG3	Autophagy	Autophagy Promotion
Beclin-1	Autophagy	Autophagy Promotion
LC3B	Autophagy	Autophagosome Formation, Protein Sorting
P62	Autophagy	Protein Sorting
PLA2G6	Autophagy	PD
TFEB	Autophagy	Autophagy Promotion, Lysosomal Biogenesis
ULK1	Autophagy	Autophagy Promotion
VPS35	Autophagy	Protein Sorting
Aldh1l1	Glial Cell Subtyping	Astrocyte
CD9	Glial Cell Subtyping	Disease-Associated Microglia
CSF1R	Glial Cell Subtyping	Microglia
Ctsd	Glial Cell Subtyping	Microglia
GPNMB	Glial Cell Subtyping	Disease-Associated Microglia
ITGAX	Glial Cell Subtyping
MSR1	Glial Cell Subtyping	Microglia
MerTK	Glial Cell Subtyping	Disease-Associated Microglia
SPP1	Glial Cell Subtyping	Disease-Associated Microglia
VIM	Glial Cell Subtyping	Vimentin, an Astrocyte marker
CD11b	Neural Cell Profiling	DC, Myeloid
CD163	Neural Cell Profiling	M2 Macrophage, Macrophage, Myeloid, Myeloid Suppression
CD31	Neural Cell Profiling	Endothelial
CD39	Neural Cell Profiling	Myeloid Suppression
CD40	Neural Cell Profiling	Myeloid, Myeloid Activation
CD45	Neural Cell Profiling	Total Immune
CD68	Neural Cell Profiling	M2 Macrophage, Macrophage, Myeloid
GFAP	Neural Cell Profiling	Astrocyte, Inflammation
IBA1	Neural Cell Profiling	Microglia
Ki-67	Neural Cell Profiling	Proliferation
MAP2	Neural Cell Profiling	Cytoskeleton, Neuron
MHC II	Neural Cell Profiling	Antigen Presentation, MHC2
MBP	Neural Cell Profiling	Myelin basic protein for Oligodendrocytes
NeuN	Neural Cell Profiling	Neuron
NfL	Neural Cell Profiling	Neurofilament light, a Cytoskeleton, Neuron
OLIG2	Neural Cell Profiling	Oligodendrocytes
S100B	Neural Cell Profiling	Antigen, Astrocyte, Inflammation, Melanoma, Tumor
SYP	Neural Cell Profiling	Synaptophysin, a Synaptic Vesicle
TMEM119	Neural Cell Profiling	Microglia
Rb IgG	Neural Cell Profiling	Background
Rt IgG2a	Neural Cell Profiling	Background
Rt IgG2b	Neural Cell Profiling	Background
GAPDH	Neural Cell Profiling	Housekeepers
Histone H3	Neural Cell Profiling	Housekeepers
S6	Neural Cell Profiling	Housekeepers

The full list detailing the specific proteins involved in the NanoString mouse neural proteomics panel. The list is split into the Autophagy module, the Glial Cell Subtyping module, and the Neural Cell Profiling core panel. Proteins denoted as “Background” are negative control proteins. Proteins denoted as “Housekeepers” are housekeeping proteins. The negative control and housekeeping proteins were used for checking the success of the assay and normalization only.

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Table 1 NanoString neural proteomic panel

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