Fig. 2: Position of the Gα13 R200K mutation identified in patients. | Nature Communications

Fig. 2: Position of the Gα13 R200K mutation identified in patients.

From: A postzygotic GNA13 variant upregulates the RHOA/ROCK pathway and alters melanocyte function in a mosaic skin hypopigmentation syndrome

Fig. 2

a 3D X-ray structure of Gα1335. The N-terminal, C-terminal and switch I domain are represented in black, dark grey and blue respectively, while the R200 residue is indicated with a red dotted arrow. b Linear representation of Gα13 showing the position of the R200 residue. The same colour code used in part a is also shown here. c Alignment of Gα13 Switch I and surrounding region in different species showing in red the fully conserved arginine which corresponds to Gα13 R200. Identical residues are represented in black and the different ones in grey. d Alignment of Gα Switch I and surrounding region showing in red the fully conserved arginine that corresponds to Gα13 R200. Identical residues are represented in black and the different ones in grey.

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