Fig. 3: Schematics, efficiency, and concentration ratios from parallelized in vitro experiments.
From: Ultra-low extracorporeal volume microfluidic leukapheresis is safe and effective in a rat model
a Overall and (b) magnified images showing a representation of a 4-CIF device setup using Y-connectors to connect the inputs, with the outputs collected into either a retentate or a filtrate tube. Scale bar = 15 cm. c, d Increasing the number of devices in parallel did not affect the collection efficiency of (c) major cell types or (d) WBC subsets. c The CIF devices still had significantly higher WBC CE as compared to RBC and PLT, with (d) the larger WBC subsets being more efficiently collected. e, f The concentration ratios of the (e) major cell types or (f) WBC subsets were also not affected by increasing the number of devices in parallel. e, f Like efficiency, the collection ratio was the highest for the (e) WBC as compared to RBC and PLT and the (f) MON. Data shown as mean ± s.e.m. n = 3 repeated measures groups. Data analyzed by 2-way RM ANOVA with Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
