Fig. 5: Interaction effects of IDO2 and childhood maltreatment on children’s depression and antidepressant efficacy. | Nature Communications

Fig. 5: Interaction effects of IDO2 and childhood maltreatment on children’s depression and antidepressant efficacy.

From: Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression

Fig. 5

Source data are provided as a Source Data file. a Shown is odds ratios (ORs) of childhood maltreatment (CM) experience (yes vs. no) on risk for new onset of child-report major depressive disorder (MDD) at 2-year follow-up using logistic regression, stratified by IDO2 genotypes. Children not diagnosed as MDD at baseline were included into analysis (N = 4,855). The center of each dot represents the OR, with error bars indicating the 95% confidence intervals (CIs). Two-tailed P < 0.05 for the gene-by-environment (G-by-E) interaction is considered as significant. b–c Shown are betas of CM on 2-year follow-up brain structural magnetic resonance imaging (sMRI) partitioned by rs28631334 and rs2340953. Linear regressions with G-by-E for sMRI at 2-year follow-up were performed. sMRI indicators used standardized values. Five sMRI indicators passed multi-correction threshold (P < 3.31e-04) are shown. The center of each dot represents the beta, with error bars indicating the 95% CIs. P-LCA: cortical area for left hemisphere cortical precuneus, OP-LCV: cortical volume for left hemisphere cortical occipital pole, MOTSLS-RSD: sulcal depth for right hemisphere cortical medial occipito-temporal sulcus and lingual sulcus, MACGS-LCT: cortical thickness for left hemisphere cortical middle-anterior part of the cingulate gyrus and sulcus, CS-RSD: sulcal depth for right hemisphere cortical central sulcus. d CM increases risk for MDD at 2-year follow-up by affecting MACGS-LCT, this path was moderated by rs28631334 genotype. e Shown is box-plot of Hamilton’s Depression Scale (HAMD) change rate at midterm-treatment refer to baseline (N = 142) across groups by CM experience and rs2340953 (TCCC/CM: n = 5, TCCC/noCM: n = 20, TT/CM: n = 30, TT/noCM: n = 87; t = 1.99, P = 0.048).The center line represents the median in each group, the black diamond represents the mean in each group, whiskers extend from the box to the minimum and maximum data points within 1.5 times the interquartile range (IQR), box limits indicate the 25th and 75th quartiles of the data, with the box representing the IQR.

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