Fig. 2: ΔsigH promotes lymphocytic immune responses in BAL post-vaccination.

Absolute counts of CD3⁺ (a), CD4⁺ (b), and CD8⁺ (c) T cells and B cells (d), in BAL at weeks 3, 5, and 7 post-vaccination time-point in BCG- () or ΔsigH- () vaccinated CMs. Each column represents an individual macaque (n = 5). Frequencies of CCR5⁺ and CXCR3⁺ - CD3⁺ (e, i), CD4⁺ (f, j), and CD8⁺ (g, k) T cells and B cells (h) in BAL. Frequencies of CCR6⁺ CD3⁺ (l), CD4⁺ (m) and CD8⁺ (n) T cells in BAL. Frequencies of CXCR3⁺CCR6⁺ CD4⁺ (o) and CD8⁺ T cells in BAL (p); effector (q), memory (r) and naïve (s) CD4⁺ T cells, CD69⁺ (t) and KI67⁺ (u) effector CD4⁺ T cells, CCR5⁺ (v), CCR7⁺ (x) and KI67⁺(z) memory CD4⁺ T cells and CCR5⁺ (w), CCR7⁺ (y) and KI67⁺(a’) memory CD8⁺ T cells in BAL at weeks 3, 5, and 7 post-vaccination time-point, expressed as percentage of parental population. Results are shown for weeks 3, 5, and 7 post-vaccination time-point (n = 5). Each column represents an individual macaque.