Fig. 3: Substrate scope for the synthesis of deuterated amino acids and their derivatives. | Nature Communications

Fig. 3: Substrate scope for the synthesis of deuterated amino acids and their derivatives.

From: Access to N-α-deuterated amino acids and DNA conjugates via Ca(II)-HFIP-mediated reductive deutero-amination of α-oxo-carbonyl compounds

Fig. 3

Standard reaction conditions: amine (0.2 mmol, 1 equiv.), carbonyl compound (1.2 equiv.), d2-HE1 (1.5 equiv.), Ca(NTf2)2 (5 mol%) in HFIP (0.2 M) at r.t. for 12 h. The yields are isolated yields. > 99% deuteration in all cases. bORTEP drawing of compound 16. Thermal ellipsoids are shown at 30% probability level.

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