Fig. 2: SAR247799 administration ameliorates colitis in mice.

a Schematic representation of DSS-induced colitis mouse model with SAR247799 (1 mg/kg) and FTY720 (0.3 mg/kg) treatments (intragastric gavage, i.g.). b, c Body weight percentage and disease activity index (DAI) (n = 6). d Representative images of colon (left) and quantification of colon length (right) (n = 6). e Representative colonoscopy images (left) and MEICS scores (right) (n = 6). f Representative images of H&E (left) and histological activity index (HAI) analysis (right). Scale bar, 200 μm (n = 6). g Schematic representation of TNBS-induced mouse colitis with SAR247799 (SAR, 1 mg/kg) and FTY720 (0.3 mg/kg) treatments (intragastric gavage, i.g.). h, i Body weight percentage and disease activity index (DAI) (n = 5). j Representative images of colon (left) and quantification of colon length (right) (n = 5). k Representative coloscopy images (left) and MEICS scoring (right) (n = 5). l Representative images of H&E (left) and HAI analysis (right). Scale bar, 200 μM (n = 5). Data are presented as mean ± SEM; Statistical analysis: two-sided Student’s t test (d–f, j–l), Two-way ANOVA with multiple comparisons (b, c, h, i). For (b and c), the significance of Ctrl+Vehicle versus DSS + Vehicle was shown as red, DSS + Vehicle versus DSS + FTY720 or DSS + SAR was shown as cyan and blue p-value respectively; For (h and i), the significance of Crtl + Vehicle versus TNBS + Vehicle was shown as red, TNBS + Vehicle versus TNBS + FTY720 or TNBS + SAR was shown as cyan and blue p-value respectively. All biological experiments were repeated three times and yielded consistent results.