Fig. 5: Pharmacological features and structural characterization of S1PR1 protein with Gi protein. | Nature Communications

Fig. 5: Pharmacological features and structural characterization of S1PR1 protein with Gi protein.

From: S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity

Fig. 5

a, b Concentration-dependent response curves of S1PR1 in response to ligands by Gαi -Gγ dissociation assay and β-arrestin recruitment. Data represent mean ± SEM from three independent experiments. c Internalization of S1PR1 in CHO cells treated with SAR247799 and FTY720-P. Data represent mean ± SEM from three independent experiments. d Overview of the cryo-EM density (left) of the S1PR1-Gi complex with SAR247799 and the model (right) of the complex structure. Light green, S1PR1; gray, SAR247799; sandy brown, Gαi1; light pink, Gβ; medium purple, Gγ.

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