Fig. 7: Additional side effect and cotreatment profile of ‘1350.
From: Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects
a Body temperatures after treatment with CP-55,940 (n = 5; one-way ANOVA, F(10, 44) = 13.3, P < 0.0001) and ‘1350 (n = 3; one-way ANOVA, F(10, 22) = 27.3, P < 0.0001). Asterisks define differences between each group 90 min. post-dose to vehicle; ‘1350 0.2 mg/kg: P < 0.0001; CP-55,940 0.2 mg/kg: P = 0.0005. b Tail flick cotreatment of morphine with ‘1350 (morphine alone and baseline n = 15, ‘1350 plus morphine n = 10, vehicle n = 5, one-way ANOVA, F(4, 50) = 14.7, P < 0.0001). Asterisks define cotreatment differences to morphine (3 mg/kg) after Dunnett’s multiple comparisons post-hoc correction; ‘1350 0.05 mg/kg: P = 0.029; 0.1 mg/kg: P < 0.0001. All data represent mean ± SEM; n denotes number of independent animals per group. ns, not significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
