Fig. 3: Fine-tuning protein foundation models improves homo-oligomer symmetry prediction and quaternary state prediction.
From: Rapid and accurate prediction of protein homo-oligomer symmetry using Seq2Symm
a Fine-tuning improves model performance across nearly every symmetry group, with the most improvements over pre-trained performance seen in rarer classes. b Seq2Symm (ESM2 fine-tuned) outperforms QUEEN, a pre-trained model from prior work on quaternary state prediction c The class-wise AUC-PR of Seq2Symm on the filtered test set.
