Fig. 4: Seq2Symm’s rapid predictions enable proteome-wide annotation of homo-oligomer symmetry.
From: Rapid and accurate prediction of protein homo-oligomer symmetry using Seq2Symm
a Proteome-wide distribution of predicted homo-oligomer symmetries in five different organisms depicted as the percentage of all proteins in the proteome reveals a higher percentage of D2 complexes in P. furiosus (an archaea) and E.coli and a higher percentage of complexes with octahedral symmetry in H. sapiens and E. pallida (a sea anemone species). b Homo-oligomer structures generated using AlphaFold2 based on some of Seq2Symm’s homo-oligomer symmetry predictions with (pLDDT, iPTM) scores shown in brackets: Q12036 (S. cerevisiae) with ‘C3’, P33348 (E. coli) with ‘C6’, P0ADR2 (E. coli) with ‘C3’, P45581 (E. coli) with ‘C3’. High structure quality metrics suggest that Seq2Symm’s predictions can aid in generating accurate structures for homo-oligomers.
