Fig. 4: Paired comparison of PFAS and OH-PCBs in individuals with MS and HC subjects.
From: Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening
A Comparisons have been made between the MS group (n = 907) and HC subjects (n = 907), patients with relapsing-remitting MS (RRMS) (n = 801), and matched HC subjects (n = 801), and between progressive MS (PMS) (n = 106) and matched HC subjects (n = 106). PFAS compounds have been grouped into three groups: short-chain PFAS (pink), long-chain PFAS (purple), and FTS (blue), while OH-PCBs (green) are listed separately. B Shows the concentration differences between MS and HC subjects when divided by sex. In (A, B) the intensity of colors represent the log2 fold change (FC) that are calculated using estimated marginal means based on a linear mixed-effect regression model and P values for the two-sided tests were computed using Satterthwaite’s degrees of freedom method. The model was adjusted for age, sex, BMI at the age of 20, BMI at the sample time point, year of sample collection, years of regular smoking, years of irregular smoking, years of indoor passive smoking, number of childbirths, and type of treatment. No adjustments were made for multiple comparisons. Source data are provided as a Source Data file. *P value <0.05; **P value <0.01.
