Table 1 Physicochemical properties and interface profiles of the optimized de novo 5HCS binders
From: Design of high-affinity binders to immune modulating receptors for cancer immunotherapy
Target | Binder ID | KD (nM) | TM (°C) | Buried surface area polar / apolar (Å2) | Convexity binder / target (1/Å) |
|---|---|---|---|---|---|
TGFβRII | 5HCS_TGFBR2_1 | < 1 | > 95 | 637.6 / 1043.2 | − 0.0669 / 0.056 |
CTLA-4 | 5HCS_CTLA4_1 | < 0.1 | > 95 | 595.6 / 1266.1 | − 0.0593 / 0.058 |
PD-L1 | 5HCS_PDL1_1 | 0.646 ± 0.02 | > 95 | 710.4 / 1108.9 | − 0.0310 / 0.001 |
